Recombinant human granulocyte/macrophage colony stimulating factor combined with hydrogel dressing for treatment of deep second degree burn wounds: a clinical observation

Zhu Yinglai; Xu Xiuling; Su Haitao; Li Yishu; Zhao Hongwei; Zhao Yannan; Kan Kan; Lv Zhuo

doi:10.3969/j.issn.1672-8521.2017.01.011

Abstract：Objective:To observe the clinical effects of recombinant human granulocyte/macrophage colony stimulating factor (rhGM-CSF) combined with hydrogel dressing for treatment of deep second degree burn wounds.Methods:Twenty-four patients of deep second degree burn wounds with 48 wound surfaces,2 wound surfaces in each patient distributed on different limps,were involved in present study.Four treatment groups were established:12 patients were randomly selected,one of their wound surface was smeared with 5 g rhGM-CSF after debridement,and then covered with topical hydrogel dressing (combination group);the other wound surface of the 12 patients was smeared with 5 g rhGM-CSF and then covered with vaseline gauze instead of topical hydrogel dressing (rhGM-CSF control group).The remained 12 patients were divided into two groups with the same method,in which vaseline gauze (vaseline gauze group) or hydrogel dressing (hydrogel dressing group) was used to cover the wound surface after debridement without rhGM-CSF.The healing time and infection of the wound surfaces were observed during the treatment.The positive rate of bacterial infection was compared among the 4 groups.Results:The wound healing time was significantly shorter in combination group than in the other three groups (P＜0.01),while it was markedly shorter in rhGM-CSF control and hydrogel dressing group when compared to that of vaseline gauze group (P＜0.05).The wound surfaces were clean in the combination group and the bacterial detection rate was lower (16.7％),and the infection of the wound surfaces was mild in rhGM-CSF control group with 25.0％ of bacterial detection rate.The bacterial detection rate from the wound surfaces was the highest (83.3％) in vaseline gauze group (P＜0.01).Conclusions:rhGM-CSF combined with hydrogel dressing used in treating deep second degree burn wound can reduce the infection rate of the wounds and significantly shorten the wound healing time.