Clinical observation on the application of dexamethasone in prevention of intracranial hemorrhage in premature infants
Mao Jin
Li Yan
Shi Yun
Lei Qiaoling
Abstract：Objective: To evaluate the clinical effect of prenatal application of dexamethasone in preventing intracranial hemorrhage in premature infants.Methods: One hundred and eighty-six premature infants (with high risk factors for preterm delivery and gestational age < 37 weeks) born in Chengdu Women and Children's Central Hospital from June 2015 to June 2016 were randomly divided into observation group (94 cases) and control group (92 cases). The gravida in observation group received intravenous injection of dexamethasone (10 mg/d for 2 days) prior to delivery, those in control group received no preventive measures. Cranial ultrasonography was performed for the premature infants 24 hours, 3 days and 7 days after birth to dynamically observe the intracranial hemorrhage, bleeding degree and progress.Results: The incidence of intracranial hemorrhage in small gestational age premature infants (< 35 weeks) of observation group was 41.54% (27/65 cases), significantly lower than that of the control group 64.06% (41/64 cases), the difference was statistically significant (P<0.05); while for the large gestational age (over 35 weeks) premature infants, no significant difference existed between the two groups in the incidence of intracranial hemorrhage (P>0.05).Conclusion: The effect of dexamethasone on preventing intracranial hemorrhage is different depending on the gestational age of premature infants, and it may play more significant role for the premature infants with gestational age of less than 35 weeks.
Keywords：Premature infantIntracranial hemorrhageDexamethasonePreventive effect
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 231-233 )