Clinical analysis of food intolerance in 312 children
Li Yanhua
Li Zhongyuan
Li Yanmei
Jiang Lihua
Hu Xiaohong
Abstract：Objective:To analyze the clinical manifestations of food intolerance in children,thus provide clinical evidence for the diagnosis and treatment of food intolerance in children.Methods:The serum allergen specific IgG antibodies to 14 kinds of food (including beef,chicken,cod,corn,crab,egg,mushroom,milk,pork,rice,shrimp,soybean,tomato,wheat) were detected with ELISA in 333 children who were highly suspected for food intolerance and underwent inefficient drug therapy,the results were analyzed in children according to their different ages.Results:Of 333 children suspected for food intolerance,312 showed positive allergen specific IgG.The cases with different clinical symptoms:respiratory system symptoms in 105 cases,digestive system symptoms in 53 cases,skin symptoms in 42 cases,nervoas system symptoms in 29 cases,malnutrition in 26 cases,precordial discomfort in 22 cases,urinary system symptoms in 11 cases,and other symptoms in 24 cases.The top four positive foods were egg,milk,soybean and tomato.The positive rate of milk intolerance was highest (79.0％) in the group of less than 1 year old,and lowest (63.0％) in the group of 4-18 years old,showing significant difference (P＜0.05).Egg intolerance rate in the groups of 2-3 years old and 4-18 years old were 95.5％and 89.5％,respectively,they were both higher than that in the group of less than 1 year (29.0％,P＜0.05).The incidence of intolerance to a single food was obviously higher in group of less than 1 year (61.3％) than in groups of 2-3 (26.1％) and 4-18years old (31.5％),showing significant differences (P＜0.01).The incidence of intolerance to 2 or more than 2 kinds of food was highest in group of 2-3 years old (73.9％),which was significantly higher than that in the group of less than 1 year (38.7％,P＜0.01),but had no significant difference with that in group of 4-18 years old (68.5％,P＞0.05).Conclusions:Multisystem diseases in children can be induced by food intolerance.Eggs and milk are the main foods that are not tolerated.Detection of the food allergen specific IgG antibody will be helpful to treat and prevent relative disease.
Keywords：ChildrenFood intoleranceFood allergen specific IgG antibody
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 157-160 )