Effect of compound chlorhexidine gargles on expression of osteopontin and alkaline phosphotase in peri-implant sulcu-lar fluid
Yang Huiying
Cui Ying
Song Xue
Abstract：Objective:To investigate the effect of compound chlorhexidine gargles on osteopontin (OPN)and alkaline phosphatase (ALP)levels in peri-implant sulcular fluid (PISF). Methods:Twenty patients were randomly divided into two groups,and each patient received transplantation of one denture. After dental implantation operation,patients in group A rinsed their mouth with 1 5 ml of 0.1 2% compound chlorhexidine as gargles after brushing teeth in the morning and in the evening as oral health care,and patients in group B rinsed their mouth with water. The PISF was collected 2 hours before operation and 1.5 months after dental implantation operation. Western blotting was used to detect the ex-pression of OPN,and enzyme linked immunoadsorbent assay (ELISA)was used to detect ALP levels in PISF. Results:The expression of OPN and ALP in PISF had no significant difference between group A and B 2 hours before operation (P>0.05). After implantation,the expression of OPN and ALP in group A was significantly lower than that in group B,and the difference was statistically significant(P<0.05).Conclusions:The compound chlorhexidine gargles can signif-icantly reduce the expression of OPN and ALP in PISF,reduce inflammation around the implant after dental implantation operation,and improve the outcome of dental implant.
Keywords：Compound chlorhexidineOsteopontinAlkaline phosphate
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 166-168 )