Study on relationship of methylenterahydro-folate reductase gene polymorphism and homocysteine in patients with cor-onary heart disease
Zhang Dongqing
Wang Haibin
Liu Miao
Abstract：Objective:To investigate the correlation between methylenterahydro-folate reductase (MTHFR)gene C677T polymorphism,homocysteine (Hcy)and coronary heart disease. Methods:Fasting blood was obtained from 172 patients with coronary heart disease and 160 healthy controls to detect the gene polymorphism of MTHFR C677T by gene chip technology. MTHFR genotype was compared between patients with coronary heart disease and healthy con-trols,and the level of serum Hcy was also compared among the coronary heart disease patients of different MTHFR gen-otypes.Results:①In coronary heart disease and control groups,the frequencies of MTHFR C677T genotype were CC 20.3% vs 32.5% (P<0.05),CT 44.8% vs 43.1% (P>0.05),and TT 34.9% vs 24.3% (P<0.05).②In coronary heart disease group,the serum Hcy level was higher than that of the control group(P<0.05).③In coronary heart dis-ease group,the serum Hcy concentration of individuals with TT genotype was higher than that of individuals with CC and CT genotype(P<0.05). Conclusions:The frequency of TT genotype of MTHFR C677T and levels of Hcy in patients with coronary heart disease are higher than the healthy controls,indicating that the polymorphism of MTHFR C677T and serum Hcy levels are related to coronary heart disease.
Keywords：Methylenterahydro-folate reductaseCoronary heart diseaseHomocysteine
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 144-147 )