Study on value of D-dimer in predicting prognosis in patients with sepsis

Yuan Shoutao; Sun Jiakui; Zheng Shuyun

doi:10.3969/j.issn.1672-8521.2014.03.004

Abstract：Objective:To evaluate the value of D-dimer in predicting the prognosis of surgical septic patients. Methods:A retrospective study was carried out with clinical data of 6 8 cases of surgical septic patients admitted in our ICU from October 2011 to March 2013. The patients were divided into three groups according to the levels of D-dimer (<0.5 mg/L,0.5-2.0 mg/L,>2.0 mg/L). The differences among the three groups stratified by acute physiology and chronic health evaluationⅡ(APACHEⅡ)score,sequential organ failure assessment (SOFA)score,mechanical ventilation (MV)time,ICU stay time,intra-abdominal hypertension (IAH)incidence,multiple organ dysfunction syndrome (MODS)incidence,and mortality were compared. The correlations between the levels of D-dimer and APACHEⅡas well as SOFA score were also analyzed. The predicting value of D-dimer on the prognosis of patients was demonstrated by the area under curve (AUC).Results:Among 68 patients enrolled,48 patients survived whereas the other 20 patients died. Patients with D-dimer>2.0 mg/L had higher SOFA scores,IAH incidence,and longer MV time and ICU stay time. Moreover,positive correlations between the levels of D-dimer and APACHEⅡ(r=0.552,P<0.01)as well as SOFA score (r=0.6 9 1 ,P<0.0 1 )were found. The levels of D-dimer had a high predictive value on the mortality (AUC=0.717)and MODS incidence (AUC=0.752)in septic patients.Conclusions:The levels of D-dimer had certain value in predictiing the severity and prognosis of surgical septic patients.