Analysis of interstitial pneumonitis following docetaxel administration
Fu Yan
Du Nan
Sun Junzhong
Li Xiaosong
Ma Junxun
Hu Jia
Zhao Hui
Kang Huanrong
Abstract：Objective:To report the treatment of severe interstitial pneumonitis in 5 patient with cancer after re-ceiving docetaxel intravenously,in order to draw due attention to the rare side-effect of docetaxel. Methods:Clincal data of the 5 patients with interstitial pneumonitis after treatment of docetaxel was analyzed. Results:Among 2 6 9 patients receiving docetaxel treatment from June 2009 to December 2013,5 patients (1.9%)suffered from inter-stitial pneumonia,including 2 patients with lung cancer,1 patient with breast cancer,1 patient with prostate canc-er and 1 patient with ovarian cancer. These patients presented acute dyspnea after 2-4 cycles of docetaxel treat-ment,and the diagnosis was established by CT examination. They received endocrine treatment (prednisone or methylprednisolone). But in 2 patients the illness ended in respiratory failure 2-5 days after appearance of symp-toms,and one of them died the next day after receiving non-invasive mechanical ventilation,and the other received mechanical ventilation and survived. Interstitial pneumonitis was ameliorated in 3 patients without respiratory fail-ure after antibiotics and endocrine treatment. Conclusions:Interstitial pneumonia is a rare and potentially fatal complication of docetaxel and need to be diagnosed and treated timely.
Keywords：DocetaxelTumorInterstitial pneumonitis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 94-97 )