Predictive value of inflammatory factors and coagulation function for abdominal infection in patients with liver cirrhosis and ascites

Wenjing Wang; Yanhua Yu

Abstract：Objective To explore the predictive value of inflammatory factors and coagulation function for abdominal infection in patients with liver cirrhosis and ascites. Methods A total of 82 patients with liver cirrhosis and ascites at Beijing You'an Hospital, Capital Medical University, from January to May 2024 were selected and divided into the infected group (n=37) and the uninfected group (n=45) according to the presence of abdominal infection. Inflammatory factors and coagulation function were compared between the two groups, and the correlations of inflammatory factors and coagulation function with abdominal infection were analyzed by Spearman's correlation. The factors influencing abdominal infection in patients with liver cirrhosis-associated ascites were identified by multivariate logistic regression. The predictive value of inflammatory factors and coagulation function for liver cirrhosis-associated ascites was evaluated by receiver operating characteristic (ROC) curve analysis. Results Among the 82 patients, there were 69 men and 12 women. The age range was 33-82 years, and the mean age was 59.2±11.5 years. There were 45 patients with abdominal infection (54.88%). Spearman's correlation analysis showed that abdominal infection was positively correlated with C-reactive protein (CRP), procalcitonin, international normalized ratio (INR), and D-dimer (DD). The multivariate logistic regression analysis showed that patients with higher CRP (odds ratio [OR] 4.701, 95% confidence interval [CI] 1.040-21.253, P=0.044), higher procalcitonin (OR 4.800, 95% CI 1.481-15.558, P=0.009), higher INR (OR 48.373, 95% CI 1.088-64.462, P=0.041), and higher DD (OR 3.441, 95% CI 1.045-11.327, P=0.042) were more likely to have abdominal infection. The area under the ROC curve (AUC) for CRP, PCT, INR, and DD for predicting abdominal infection in patients with liver cirrhosis-associated ascites was 0.759 (95% CI 0.655-0.863, P=0.000), 0.756 (95% CI 0.648-0.864, P=0.000), 0.636 (95% CI 0.513-0.757, P=0.036), and 0.659 (95% CI 0.541-0.778, P=0.014), respectively, with sensitivity values of 0.8667, 0.7778, 0.7556, and 0.5111, respectively, and specificity values of 0.5405, 0.7027, 0.4865, and 0.8378, respectively. Conclusion Inflammatory factors and coagulation function have high predictive value for abdominal infection in patients with liver cirrhosis-associated ascites and may be important references for clinical treatment.