Therapeutic effect of Nanyang kiwifruit extract on oral ulcer

Tao Liu; Xintong Nie; Wenjuan Du; Rui Xiao

Abstract：Objective This study aimed to examine the pharmacodynamic effects of Nanyang kiwifruit extract on rats with traumatic oral ulcers and to provide a theoretical basis for its potential clinical application in treating oral mucosal diseases. Methods Fifty-four male Sprague Dawley rats were acclimatized for 1 week before being subjected to chemical cauterization to induce oral ulcers. The rats were then divided into six groups: the control group, the model group, Nanyang kiwifruit extract/hydroxyapatite group, the hydroxyapatite group, the ordinary kiwifruit extract group, and Nanyang kiwifruit extract group. The evaluation indicators included the state of ulcer healing, the ulcer area, and the healing period. To assess the pathology of the wounds, three rats from each group were randomly selected on the third and fifth days of drug administration for hematoxylin and eosin (HE) staining. Results Compared with the other groups, Nanyang kiwifruit extract and Nanyang kiwifruit extract/hydroxyapatite group demonstrated a significant reduction in the healing time of oral ulcers, as evidenced by both observation and the HE staining results. The HE staining further revealed that the mucosal epithelium healed more rapidly and the edema recovered faster in the Nanyang kiwifruit extract group and Nanyang kiwifruit extract/hydroxyapatite group than in the other groups. These findings indicate that the Nanyang kiwifruit extract group and Nanyang kiwifruit extract/hydroxyapatite group had a pronounced effect on promoting ulcer healing. Conclusion Nanyang kiwifruit extract and the hydroxyapatite effectively promote ulcer healing and reduce the healing time of oral ulcer wounds.