Research progress of stem cells in basic research and intervention therapy of atrial fibrillation
FENG Zibei
CHEN Chengdi
HE Yuan
HUANG Shian
Abstract：Atrial fibrillation(AF)is one of the most common arrhythmias in clinical practice.However,its mechanism has not been fully elucidated,and there are many problems in the treatment of AF,such as high recurrence rate,large side effects and unstable therapeutic effect.In recent years,stem cells have shown great application prospects in the field of cardiovascular disease research and treatment because of their multi-directional differentiation potential and the function of mesenchymal stem cells(MSCs)to secrete exosomes.This article analyzes recent advancements of stem cells in the mechanism and intervention of AF,including the use of stem cells to construct an in vitro AF models,drug screening based on this models,and elucidates molecular mechanisms of AF combined with reprogramming or gene editing technologies.Furthermore,we explore the effect of mesenchymal stem cells on improving myocardial fibrosis by secreting exosomes.It provides a new direction for the treatment of AF in the future.
Keywords：stem cellsatrial fibrillationinduced pluripotent stem cellstherapydisease model
Publication Date：2025-12-30
Online Publishing Date：2025-12-11(First online date of this platform, not the publication date of the document)
Pages：7( 648-654 )