Research progress on the regulatory roles of lactate immunometabolism and lactylation in pulmonary inflammatory diseases
DENG Jingyi
YANG Shenyue
OUYANG Suidong
Abstract：As the terminal metabolite of glycolysis,lactate plays a critical role in regulating immune responses,energy metabolism,and the development of inflammatory diseases.Recent studies have demonstrated that lactate metabolism and lactylation modifications,by influencing the reprogramming of energy metabolism and epigenetic regulation in immune cells,modulate the intensity,duration,and tissue specificity of immune responses.Additionally,these processes may be implicated in the onset and progression of pulmonary inflammatory diseases such as pulmonary infections,asthma,chronic obstructive pulmonary disease(COPD),and pulmonary fibrosis.This review summarizes the regulatory mechanisms of lactate immunometabolism and lactylation modifications in immune cells and pulmonary inflammatory diseases,and further discusses potential therapeutic strategies targeting these pathways,aiming to provide new theoretical foundations and research directions for the precision treatment of pulmonary inflammatory diseases.
Keywords：lactateimmunometabolismlactylationpulmonary inflammatory diseases
Publication Date：2025-10-30
Online Publishing Date：2025-10-31(First online date of this platform, not the publication date of the document)
Pages：12( 447-458 )