Advances in cGAS-STING pathway-mediated cellular senescence in aging and age-related diseases
LIU Xiaomeng
WU Jianfeng
YANG Xiaojun
Abstract：The cGAS-STING signaling pathway,a critical regulator of the innate immune system,has recently been identified as a core driver of age-related inflammation and functional decline.Furthermore,it has been demonstrated to be involved in multiple senescence-associated disease processes.This review summarizes the research progress of the cGAS-STING signaling pathway as an influencing factor in the regulation of cellular senescence and its biological functions in aging-related diseases,and further analyzes the role of cGAS-STING in regulating diverse aging-related cellular functions,including inflammation,tumorigenesis,mitochondrial dysfunction,DNA damage,as well as the biological dysfunctions related to the aging-related diseases.Furthermore,the review sums up the clinical significance and potential of cGAS-STING targeted therapy for aging-related diseases,alongside the challenges encountered.The development of cGAS-STING antagonists or agonists,may provide novel strategies for targeting the cGAS-STING pathway in the treatment of aging-related diseases.
Keywords：cGAS-STINGcellular senescenceinflammationage-related disease
Publication Date：2025-06-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：10( 217-226 )