Research advances on the role of Sirtuin 3 in diabetic cardiomyopathy
FENG Taoshan
MA Guoda
CHEN Xiaoming
Abstract：Diabetic cardiomyopathy(DCM)is a severe cardiovascular complication resulting from persistent hyperglycemia and hyperinsulinemia in diabetic patients,showing a high mortality rate.Sirtuin 3(SIRT3)is a nicotinamide adenine dinucleotide(NAD+)-dependent deacetylase that participates in various signaling pathways to regulate oxidative stress,mitochondrial function,apoptosis,and other pathophysiological processes,thereby exerting a protective effect in DCM.This review provides an overview of the latest research progress on SIRT3,focusing particularly on its involvement in regulating cardiac mitochondrial metabolism and function in the context of DCM.
Keywords：diabetesdiabetic cardiomyopathySirtuin 3cardiac mitochondria
Publication Date：2025-04-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：11( 200-210 )