BiPAP combined with oxygen-driven budesonide nebulization improves clinical indicators in acute exacerbation of chronic obstructive pulmonary diseases with type 2 diabetes
YAO Guanjin
LIN Huibin
HUANG Yaoguang
MA Biman
Abstract：Objective To observe the efficacy of bi-level positive airway pressure ventilator(BiPAP)and oxygen-driven aerosol inhalation of budesonide in patients with acute exacerbation of chronic obstructive pulmonary diseases(AECOPD)and type 2 diabetes mellitus(T2DM).Methods A total of 110 AECOPD patients with T2DM were randomly treated with BiPAP(control group)or BiPAP plus oxygen-driven budesonide nebulization(observation group)for 7 days.Clinical efficacy,adverse reactions,blood gas,vital signs,inflammatory response,stress response,glucose metabolism,and pulmonary function indexes were compared between two groups.Results Compared with control group,PaCO2,heart rate,respiration,hs-CRP,WBC,MDA,DI were significantly decreased,while PaO2,SOD,FEV1%and FEV1/FVC increased in observation group(P<0.01 or 0.05).The curative effect was better in observation group than in control group(P<0.05).Conclusion BiPAP combined with oxygen-driven budesonide nebulization can improve the curative effect as well as blood gas,vital signs,inflammatory response,stress response and pulmonary function in patients with AECOPD and T2DM.
Keywords：acute exacerbation of chronic obstructive pulmonary diseasestype2 diabetesbilevel positive airway pressure ventilatoroxygen driven nebulizationbudesonide
Publication Date：2025-04-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 189-193 )