The role of dendritic cells in the pathogenesis and therapeutic value of allergic diseases
MAO Pei
WANG Yanyan
HUANG Gonghua
Abstract：Allergic diseases are inflammatory conditions caused by inappropriate or excessive immune responses to certain environmental allergens.The underlying mechanisms remain incompletely understood.Dendritic cell(DC)play a pivotal role as key upstream factors of allergic reactions,particularly in orchestrating allergen presentation and T cell immune response induction.DC are critically implicated in the pathogenesis of diverse allergic diseases,including allergic asthma,atopic dermatitis,and food allergies.Many therapeutic strategies targeting DC in allergic diseases have been developed through functional studies.Here,we review the biological characteristics of DC,discuss the roles of distinct DC subsets in the pathogenesis of allergic diseases,and highlight the advances in DC-centered therapies,providing new strategies for treating allergic diseases by targeting DC.
Keywords：dendritic cellallergic diseaseimmunomodulation
Publication Date：2025-04-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 131-138 )