Research progress on the relationship between Parkinson's disease and the skeletal system
ZHANG Renjie
LUO Yue
BAO Bo
Abstract：Parkinson's disease(PD)is a chronic neurodegenerative disorder marked by both motor and non-motor symptoms,significantly impeding daily activities.Recent molecular,biological,and genetic investigations reveal the expression of PD susceptibility genes in peripheral organs and tissues,including bone cells,suggesting that PD may be classified as a systemic ailment.Evidence increasingly supports that individuals with PD are at heightened risk for osteoporosis and fractures,displaying a substantially greater incidence of fractures compared to age-matched controls.This article elaborates on the research progress of the correlation between Parkinson's disease and the skeletal system,aiming to provide a reference for the assessment,management,treatment,and potential research directions of bone health in Parkinson's disease patients.
Keywords：Parkinson's disease(PD)osteoporosisbone metabolisminterdisciplinary dialoguepathophysiological mechanisms
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 103-108 )