Research progress on the resistance mechanism of Podophyllotoxin and its derivatives
CHEN Xin
LU Xiaomei
LIU Yuyu
Abstract：Podophyllotoxin is a natural product-derived drug with a long history of medicinal use,has led to the discovery of various derivatives in drug development.Despite their widespread clinical application,particularly in anti-tumor therapy,as tumor cells gradually develop resistance to podophyllotoxin and its derivatives during chemotherapy.Therefore,as tumor cells gradually develop resistance to podophyllotoxin and its derivatives during clinical chemotherapy,this review discuss the mechanisms of resistance to podophyllotoxin and its derivatives,providing references for predicting and avoiding resistance,and improving the clinical efficacy of podophyllotoxin and its derivatives.
Keywords：podophyllotoxinetoposidepodophyllotoxin derivativesdrug resistance mechanism
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 628-635 )