Application and prospect of proteolysis targeting chimeric technology and its natural product-derived molecules in breast cancer treatment
LUO Yingmei
GAO Yin
ZHENG Jia
Abstract：Breast cancer has become the most prevalent malignancy among women globally,with an increasing incidence rate.Traditional treatment modalities such as chemotherapy,endocrine therapy,and molecular targeted therapy have achieved certain clinical successes,but their effectiveness is severely compromised by drug resistance issues.Proteolysis Targeting Chimeric(PROTAC)technology,as an emerging protein degradation strategy,offers new possibilities for treating drug-resistant breast cancer,particularly PROTAC molecules derived from natural products exhibited great potential.This review summarized the current status and future trends of PROTAC technology in breast cancer treatment.It focuses on PROTAC research progress targeting different molecular subtypes of breast cancer,delves into the design of PROTAC molecules based on natural products,and explores their potential value in breast cancer treatment.Additionally,the review provides new insights into the prospects of marine drugs developed based on PROTAC technology in breast cancer treatment.
Keywords：breast cancerproteolysis targeting chimericnatural productstarget
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：11( 545-555 )