Research progress on the role of apoptosis in the tumor microenvironment
XU Tao
HUANG Huiqun
GAO Yuting
Abstract：Apoptosis,a process of programmed cell death,is important in tumor research because it involves the timely removal of aged,damaged or abnormal cells and prevents their further growth and spread.The tumor microenvironment(TME)provides the necessary survival conditions for tumor initiation and progression.Through the inhibition of the apoptotic pathways or the enhancement of anti-apoptotic pathways,tumor cells might evade the normal process of cellular self-destruction in this complex environment.This can result in uncontrolled growth and drug resistance.In order to provide a theoretical foundation for the development of more focused anti-cancer treatments,this article reviews recent developments in the study of apoptosis in tumorigenesis and development from a TME viewpoint.
Keywords：apoptosistumor microenvironmentdrug resistancereview
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 501-506 )