Clinical observation of alteplase and ginkgo diterpene lactone meglumine on acute ischemic stroke with MRI DWI/FLAIR mismatch
LIANG Ri-qing
XIAO Yuan-liu
LIN Xian
XIAO Jing-hui
LIANG Zai
Abstract：Objective To observe the efficacy of combined alteplase and ginkgo diterpene lactone meglumine(GDLM)in acute ischemic stroke(AIS)with magnetic resonance imaging diffusion weighted imaging/fluid attenuated inversion recovery(MRI DWI/FLAIR)mismatch.Methods Ninety-four AIS patients with MRI DWI/FLAIR mismatch were randomly treated with alteplase(control group)or alteplase and GDLM(observation group)for 2 weeks.Clinical efficacy,serum inflammatory factors(IL-6,IL-8,IL-1β,and hs-CRP),hemorheological indicators,and adverse reactions were compared between 2 groups.Results The curative effect was better in observation group than in control group(P<0.05),but no significant difference of adverse reactions was noted between 2 groups(P>0.05).Levels of IL-6,IL-8,hs-CRP and IL-1β and hemorheological parameters were lower after therapy in both groups,especially in observation group(P<0.01 or 0.05).Conclusion Clinical efficacy of combined alteplase and GDLM is superior to that of alteplase in AIS patients with MRI DWI/FLAIR mismatched by reducing inflammatory cytokines and improving hemorheological indicators.
Keywords：MRI DWI/FLAIR mismatchacute ischemic strokealteplaseginkgo diterpene lactone meglumine
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 413-416 )