Correlation analysis of serum oxLDL,CTRP5,MCP-1 expression levels and carotid atherosclerosis in hypertensive patients

ZHU Wan-jie; ZHANG Juan; SI Yuan-yuan

doi:10.3969/j.issn.1005-4057.2024.04.011

Abstract：Objective The aim of this study is to determine the correlation between serum oxidized low-density lipoprotein(oxLDL),complement C1q/tumor necrosis factor related protein 5(CTRP5)and monocyte chemotactic protein-1(MCP-1)and hypertensive carotid atherosclerosis(CAS).Methods Based on the carotid intima-media thickness(CIMT),143 hypertensive patients were divided into two groups:a normal group(n=61)and a CAS group(n=82).Additionally,87 healthy individuals who underwent physical examinations were included in the control group.ELISA method was applied to measure serum levels of oxLDL,CTRP5,and MCP-1.The relationship between serum oxLDL,CTRP5,MCP-1 levels and CIMT was analyzed using Pearson correlation method.Logistic regression method was applied to explore the influencing factors of CAS occurrence in hypertensive patients.The diagnostic value of serum oxLDL,CTRP5,and MCP-1 in hypertensive CAS was investigated using receiver operating characteristic(ROC)curves.Results The levels of serum oxLDL,CTRP5,and MCP-1 in the control group,normal group,and CAS group all increased sequentially(P<0.05).Pearson analysis showed a significant positive correlation between serum oxLDL,CTRP5,MCP-1 and CIMT(r=0.526,0.592,0.646,P<0.05).Logistic regression analysis suggested that homocysteine(Hcy),high-density lipoprotein(HDL-C),oxLDL,CTRP5,and MCP-1 were all influencing factors for the occurrence of CAS in hypertensive patients(P<0.05).The AUC of oxLDL,CTRP5 and MCP-1 combined diagnosis was significantly higher than that of each index alone diagnosis(P<0.05).Conclusion The levels of serum oxLDL,CTRP5,and MCP-1 are all elevated in hypertensive CAS patients,and their expression levels are positively correlated with CIMT.Moreover,these three factors demostrate high diagnostic efficacy in diagnosing hypertensive CAS.