Causal mediation analysis of Calf Circumference,HCAR and Cognitive Impairment in older adults-based on CLHLS2014 data
XU Yin-wen
HU Tian
TIAN Qing-qing
LIU Zhou
Abstract：Objective This study aims to investigate the relationship between calf circumference and cognitive impairment and to study the mediating role of the hypersensitive C-reactive protein(hs-CRP)/albumin ratio(HCAR).Methods Data in the 2014 CLHLS database were analyzed,and 1 784 study participants were finally included in this study.Cognitive function was assessed by the Chinese version of the brief mental state examination(cMMSE).Data were processed and analysed using R software,and mediating effects were verified using Bootstrap sampling.Results After correcting for multiple factors,calf circumference was significantly negatively associated with cognitive impairment(OR=0.951,95％CI:0.933-0.970),in which HCAR played a mediating role(mediating effect ratio 0.022,95％CI:0.002-0.060).Conclusion There is a negative association between calf circumference and cognitive impairment,in with HCAR plays a mediating role.This finding has important implications for the prevention and intervention of cognitive impairment.
Keywords：high-sensitivity C-reactive protein(hs-CRP)/albumin ratio(HCAR)calf circumferencecognitive impairmentMediation analysisChinese longitudinal healthy longevity survey(CLHLS)database
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 162-168 )