A clinical and molecular characteristics study of Klebsiella pneumoniae infection with highly invasive mucinous pneumonia
LIU Zhi-yun
LIANG Xue-yan
CAO Hai-yan
LI Lu
LI Ge-ge
ZHONG Ying-ying
XIAN Zhi-li
WU Xian-jin
Abstract：Objective This study aims to analyze the clinical and molecular characteristics of patients with invasive mucinous Klebsiella pneumoniae(HMVKP)infection,providing evidence for precise diagnosis and clinical antimicrobial therapy of invasive mucinous Klebsiella pneumoniae infection.Methods Clinical data of patients with invasive mucinous Klebsiella pneumoniae infection were analyzed,and molecular characteristics including capsule serotype,virulence genes,and drug resistance genes were detected using PCR.Results Among the 96 strains of invasive Klebsiella pneumoniae,64 strains were identified as HMVKP,with pus(32.8％)being the most common specimen in the HMVKP group.Four ESBL-producing strains and two carbapenem-resistant strains were detected among the HMVKP strains.The predominant capsule serotypes of HMVKP were K1(40.6％)and K2(29.7％),while the highest prevalence of virulence genes were peg344,iucA,and iroB.Seven virulence genes(peg344,rmpA,rmpA2,magA,iucA,iroB,and kfu)showed statistically significant differences between the HMVKP and non-HMVKP groups(P＜0.05).Conclusion K1 and K2 are the most common capsule serotypes of invasive HMVKP in this region,while peg344,iucA,iroB,and rmpA are the main virulence genes.Multiple drug-resistant HMVKP strains,especially those resistant to carbapenems,have emerged,necessitating heightened awareness.
Keywords：Klebsiella pneumoniaehigh viscosityinvasive infectiondrug resistancecapsular serotypevirulence genes
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 157-161,168 )