Role of protein translational modifications in hepatic fibrosis
CHEN Jun-ming
LIAO Lin-rong
WEN You-liang
DIAO Ying-xiu
QU Jia-yang
PAN Jia-hui
Abstract：Hepatic fibrosis(HF)is complex pathological process that is regulated by a variety of cells,mediators,and signaling pathways,and leads to excessive deposition of extracellular matrix and collagens.Protein translational modifications(PTMs)are chemical modifications of substrates and functional groups after DNA is transcribed into mRNA and further translated into proteins.The HF process undergoes extensive PTMs.This paper reviews the role of protein phosphorylation and nitrosylation in HF.
Keywords：hepatic fibrosisPTMsphosphorylationnitrosylation
Publication Date：2024-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 99-104 )