Clinical effect of dapagliflozin on acute myocardial injury in patients with type 2 diabetes mellitus and heart failure
LI Shang-hai
HUANG Chun-yan
FAN Jun-yu
LIANG Wei-jun
HUANG Rui-na
Abstract：Objective To observe the effect of dapagliflozin on acute myocardial injury in patients with type 2 diabetes mellitus(T2DM)and heart failure.Methods Sixty-eight patients with T2DM and heart failure were treated with conventional anti-heart failure therapy(n=32,control group)or combined dapagliflozin(n=36,observation group).Myocardial injury markers,inflammatory cytokines,major adverse cardiovascular events(MACE),and rehospitalization of recurrent heart failure were compared between two groups.Results Compared with control group,levels of N-terminal pro-B-type natriuretic peptide(NT-proBNP),high sensitivity cardiac troponin T(Hs-TnT),TNF-α,IL-1β,IL-6,C-reactive protein(CRP),MACE,and rehospitalization of recurrent heart failure were lower in observation group(P<0.01 or 0.05).Conclusion Dapagliflozin can improve acute myocardial injury and inflammatory cytokines in patients with T2DM and heart failure.
Keywords：dapagliflozinheart failuretype 2 diabetes mellitusmyocardial injury
Publication Date：2024-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 82-85 )