Significance of serum TNF-α levels in patients with diabetic retinopathy
WANG Li-yu
SUN Hong-yan
WANG Jing
ZHAO Hui-pan
ZHENG Xiu-jin
WANG Jun
LIU Li-lian
YANG Ming-ming
LIAO Hai-lan
Abstract：Objective To analyze the significance of serum TNF-α levels in patients with diabetic retinopathy(DR).Methods Serum levels of TNF-α and biochemical indexes were determined in 115 DR,117 type 2 diabetes mellitus(DM),and 121 simple cataract(control group)patients.Results Serum TNF-α levels were higher in DR and DM groups than in control group,especially in DR group(P<0.05).In DR group,serum TNF-α concentrations were positively correlated with creatinine,blood urea nitrogen,uric acid,and systolic blood pressure,and negatively with eGFR and HDL-C(P<0.01 or 0.05).ROC curve analysis showed that the area under the curve of TNF-α was 0.611.Conclusion Serum TNF-α levels are associated with renal injury indicators in DR patients.
Keywords：diabetic retinopathytumor necrosis factor-αrenal function
Publication Date：2024-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 78-81 )