Action mechanism of Salvia miltiorrhiza in femoral head necrosis based on network pharmacology and molecular docking
CHEN Ze-yu
LIANG Hong-ying
LUO Shi-ying
ZHANG Yi-ting
CHEN yan
Abstract：Objective To explore the action mechanism of Salvia miltiorrhiza(Sm)in osteonecrosis of femoral head(ONFH)using network pharmacology and molecular docking.Methods The active components and targets of Sm were screened by TCMSP,while disease targets of ONFH were collected by OMIM,GeneCards,NCBI and DisGeNET databases.The intersection targets between Sm and ONFH were analyzed by Jevnn,GO and KEGG.The network diagram of"component-target-disease"was drawn by Cytoscape software,and the core components and intersection targets were verified by molecular docking.Results Seventy-four intersecting targets between Sm and ONFH were screened,mainly including EZH2,CYP19A1,EGFR,PTPN6 and OPRM1.There were 19 core components of Sm against ONFH,such as luteolin,salvianolic acid C,isotanshinone II,tanshinone IIA,etc.of 237 potential regulatory pathways,AGE/RAGE,fluid shear stress,atherosclerosis,and TNF were most common.Molecular docking showed that tanshinone IIA and luteolin had potential binding activities with EZH2 and EGFR.Conclusion Sm can play a role in ONFH through multiple components and targets,which may be mainly related to vascular endothelial proliferation,osteocyte differentiation and hemodynamics.
Keywords：Salvia miltiorrhizafemoral head necrosisnetwork pharmacology
Publication Date：2024-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 39-46 )