Preparation and antibacterial efficacy of chemical and photothermal antibacterial dressing based on sodium alginate composite apple polyphenols
ZHAO Sheng-lan
CHEN Jia
XU Yue-ying
LIU Zhong-jia
GUO Ning
FENG Xiao-ya
Abstract：Objective To prepare a new type of chemical and photothermal non-antibiotic wound antibacterial dressing for bacterial infections.Methods The sponge-ike skeleton of photothermal antibacterial dressing SA/APP/Fe3+(SAF)was prepared by freeze-drying in situ and non-covalent crosslinking using Fe3+,sodium alginate,and apple polyphenol.Its biological safety,hemostatic ability and bactericidal ability were testified by in vitro experiments.Results Under near-infrared radiation,SAF antibacterial dressing killed nearly 80%of Staphylococcus aureus and 85%of Escherichia coli.The cell survival rate of SAF antibacterial dressing was more than 95%,and hemolysis rate was 6.75%.Compared with gauze,SAF antibacterial dressing reduced blood loss by 26%and hemostatic time by 76%.Conclusion This antibacterial dressing has strong antibacterial effect,high biological safety and hemostatic ability.
Keywords：sodium alginateapple polyphenolsantibacterial dressing
Publication Date：2024-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 17-24 )