Correlation of IL-13,IL-4,ADRβ2,FcεRI-β single nucleotide polymorphism with curative effect and clinical outcome of relapse wheezing in children

WANG Lian; ZHAO Teng-fei; NIU Si-juan

doi:10.3969/j.issn.1005-4057.2023.06.017

Abstract：Objective To explore the correlation between IL-13,IL-4,ADRβ2,and FcεRI-β single nucleotide polymorphism(SNP)and the curative effect and clinical outcome of relapse wheezing in children.Methods A total of 60 children with relapse wheezing of asthmatic bronchitis were selected as the research subjects.The primes of IL-13 rs20541,IL-4 rs2243250,ADRβ2 R16G and FcεRI-β E237G sites were designed to test the SNP of IL-13,IL-4,ADRβ2 and FcεRI-β,and the correlation of SNP of each genetic locus with the curative effect and clinical outcome in children was analyzed.Results The total effective rates of IL-13 rs20541 wild type AA and heterozygous type GA was higher than that of homozygous type GG(P＜0.01).There were statistical differences in the effective rate among different genotypes of ADRβ2 R16G(P＜0.01),of which the effective rate of the genotype GG was higher than that of the genotype AA and AG(P＜0.05).for the comparison of the effective rate of different genotypes of FcεRI-β E237G,AA＞AG＞GG(P＜0.05).The incidence of persistent wheezing of IL-13 rs20541 wild type AA and heterozygous type GA was lower than that of homozygous type GG(P＜0.05).There were statistical differences in the outcome among different genotypes of ADRβ2 R16G(P＜0.05),of which the incidence of persistent wheezing of the genotype GG was higher than that of the genotype AA and AG(P＜0.05).For the incidence of persistent wheezing of different genotypes of FcεRI-β E237G,GG＞AA＞AG(P＜0.05).Conclusion IL-13 rs20541,ADRβ2 R16G,and FcεRI-βE237G SNPs are correlated with the curative effect and clinical outcome of children.