Genotype distribution of high-risk human papillomavirus in Shunde District,Foshan City and its correlation with cervical lesions
LIANG Li-yi
HUANG Jin-zhi
YIN He-xuan
LIU Yu-xi
ZHONG Hua
Abstract：Objective To understand the genotype distribution of high-risk human papillomavirus(HR-HPV)in Shunde District,Foshan City and the relationship between HR-HPV infection and cervical lesions.Methods The clinical data of 3466 women who sought medical treatment at gynecological clinic,were HR-HPV positive and had no history of physical or surgical treatment for cervix were collected and multivariate logistic regression was used to analyze the relationship between HPV genotypes and cervical lesions.Results Among the patients with cervical precancerous lesions and cervical cancer,the top 5 HPV sub-genotypes were HPV16,52,58,51,and 33,mostly HPV Alpha 9 family genotypes(the A9 Group).Among the females with HR-HPV positive who underwent biopsy,the genotypes with the highest detection rate for high-grade squamous intraepithelial lesion(HSIL)were HPV33,16,31,58,and 51.The positive rate of HSIL in HPV51 multiple infection was higher than that in HPV51 single infection(P＜0.01),and the other types of infection were not correlated with the degree of cervical lesions(P＞0.05).The most common multiple infections were co-infection of HPV16 and HPV52(77),followed by co-infection of HPV52 and HPV58(52).Infection with the HPV16/18 sub-genotype and sub-genotypes of HPV A9 group(HPV31,33,35,52,and 58),age,and TCT abnormalities were all independent risk factors for cervical precancerous lesions/cervical cancer(P＜0.01).Conclusion HR-HPV positive elderly women with HPV16,18,31,33,35,52,and 58 infection and abnormal TCT have a higher risk of cervical lesions.
Keywords：high-risk human papillomaviruscervical precancerous lesionscervical cancerepidemiologyShunde Foshan
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 663-669 )