Evaluation of PD-L1 expression and fibrinogen-neutrophil/lymphocyte ratio on clinical efficacy of relapsed/refractory diffuse large B-cell lymphoma
LV Xue-wen
ZHANG Qian
CHEN Huan-wei
Abstract：Objective To evaluate the value of programmed death ligand 1(PD-L1)expression and fibrinogen-neutrophil/lymphocyte ratio(F-NLR)on therapeutic efficacy of relapsed/refractory diffuse large B-cell lymphoma(R/R DLBCL).Methods PD-L1 expression was detected by immunohistochemistry in pathological tissues of 40 R/R DLBCL cases.Blood fibrinogen,neutrophil,and lymphocyte levels were determined before and after chemotherapy.The relationship between PD-L1 expression,F-NLR and therapeutic effect was analyzed.Results Forty patients with R/R DLBCL received second-line chemotherapy,of whom 18 were effective and 22 ineffective.Tumor proportion score(TPS)and combined positive score(CPS)were positive in 9(22.5％)and 17(42.5％)cases,respectively.The chemotherapy efficacy was lower in CPS-positive and F-NLR 1-2 groups than in CPS-negative and F-NLR 0 groups(P＜0.05),and so did in TPS-negative or CPS-positive plus F-NLR 2 groups compared with F-NLR 0 group(P＜0.05).Conclusion CPS plus F-NLR may be helpful in judging the clinical efficacy of R/R DLBCL.
Keywords：relapsed/refractory diffuse large B-cell lymphomaprogrammed death ligandfibrinogen
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 649-652 )