Expressions of PD-1 and PD-L1 in peripheral blood and placental tissues of preeclampsia pregnant women and their significance
JIANG Yan-yan
MIAO Li-lin
LIU Hui-zhen
YIN Li-ming
Abstract：Objective To analyze the expression of PD-1 and PD-L1 in peripheral blood and placental tissues of patients with preeclampsia and their significance.Methods The expressions of PD-1 and PD-L1 on the surface of peripheral blood T lymphocytes and in placental tissues in 30 preeclampsia pregnant women(Observation Group,n=30)and 30 normal pregnant women(Control Group,n=30)were determined by flow cytometry and immunohistochemistry,and their correlation with the mean arterial pressure,24 h urine protein and other indicators of the pregnant women were analyzed.Results The expressions of PD-1 and PD-L1 on the surface of peripheral blood T lymphocytes and in placental tissues in the Observation Group were significantly lower than those in the Control Group(P＜0.05).The expressions of PD-1 and PD-L1 in peripheral blood were positively correlated with those in placental tissue(r=0.432 and 0.377,P＜0.05 for all).The expressions of PD-1 and PD-L1 were negatively correlated with mean arterial pressure and 24-hour urine protein of the pregnant women(P＜0.05).Conclusion The expressions of PD-1 and PD-L1 in the peripheral blood of pregnant women with preeclampsia can reflect the expressions of PD-1 and PD-L1 in placenta tissues,and also reflect the severity of preeclampsia.
Keywords：preeclampsiaprogrammed death receptor-1programmed death receptor-ligand 1pathogenesis
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 628-630 )