The effect of expression of E-cadherin and β-catenin on bcl-2 expression in nasopharyngeal carcinoma
CHU Bing
JI Min-fang
CAO Shi-hua
Abstract：Objective：To investigate the effect of expression of E-cadherin and β-catenin on bcl-2 expression in nasopharyngeal carcinoma（NPC）．Methods：The expression of E-cadherin，β-catenin and bcl-2 was detected with immunohistochemical technique in 74 cases of NPC samples．The information was analyzed with Wilcoxon signed rank test．Results：E-cadherin，β-catenin and Bcl-2 were expressed in 72，73 and 65 cases of NPC，respectively，and the positive cells of each case ranged from 5％ to 100％．The median positive percentage of bcl-2 was significantly lower than that of E-cadherin and β-catenin in NPC（P＝0．003 and 0．001，respectively），and the higher expression of E-cadherin and β-catenin，the lower expression of bcl-2．In addition，the expression of bcl-2 in 24 cases with cytoplasmic expression of β-catenin was lower than that without cytoplasmic expression（P＝0．041）．Conclusion：Enhanced expression of E-cadherin may reduce bcl-2 expression in NPC，and the ectopic expression of β-catenin may play an important role in the regulation of bcl-2 expression．
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 90-91 )