The role of proteinase in the invasion process of human lung cancer cells
SHEN Xiao-ming
HUANG Wei
HUANG Ji qun
Abstract：To investigate the role of type Ⅳ collogenase，urokinase plasminogen activator（u-PA） and cathepsin B（CB） in the invasion process of high metastatic human lung cancer cell subline（PGCL3）．Method：Three proteinases inhibitors，EDTA for type Ⅳ collagenase，trans-4-（aminomethy1）-cyclohexanecarboxylic acid（TA） for u-PA and N-ethylmaleimide（NEM） for CB，were chosen to observe their effects on the abilities of degrading and crossing the reconstructive matrigel of PGCL3 cells．The inhibitors were：inhibitor of cathepsin B）．Results：Both TA and NEM could significantly inhibit the ability of invasion of PGCL3 cells，whereas EDTA appeared to have no inhibition． Conclusion：Both u-PA and CB are important enzymes in PGCL3 cell invasion，and the inhibition of u-PA and CB may be a prospective therapy of carcinoma．
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 81-82 )