Effect of intravenous omeprazole and high dosage of oral noradrenaline on rapid hemostasis for upper gastrointestinal hemorrhage
GUAN Cai-ping
Abstract：Objective：To probe into a safe effective rapid hemostasia for upper gastrointestinal hemorrhage（UGIH）．Methods：87 patients with UGIH were randomly divided into two groups（Group A and Group B）．The patients in Group A（n＝47）were intravenously given omeprazole of 40 mg every 12 hours combined with 0．4 g／L noradrenaline 20 mL orally every hour within initial 6 hours，followed with every 2 to 4 hours according to hemorrhagic conditions．Omeprazole was orally given instead after three days．Once hemostasis could be gained，noradrenaline was discontinued．The patients in Group B（n＝40）received only omeprazole as its usage and dosage as in Group A．Results：The efficacy of hemosatasis in Group A was significantly better than that in Group B（Hc＝5．852 P＜0．05）．The rate of rapid hemostasis （within 12 hours）and total effective rate were substantially greater in Group A compared with those in Group B（68．1％ vs 45．0％，93．6％ vs 77．5％，respectively，P＜0．05）．No obvious side-effects were observed．Gastric mucosa necrosis under gastroscopy did not occur in Group A when high dosage of noradrenaline had been orally given for 12 hours．Conclusion：Intravenous omeprazole combined with high dosage of orally noradrenaline may play rapid hemostatic role in upper gastrointestinal hemorrhage and suits to critical hemostasis of UGIH at local hospital before the victims will be taken to medical center．
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 26-28 )