Plasma levels of P-seletin and laminin in patients with lung cancer and their clinical significance
Abstract：Objective：To study the plasma levels of P-selectin（P-sel）and laminin（LN）in patients with lung cancer and their clinical significance．Methods：The plasma levels of P-sel and LN were detected by ELISA in 85 patients with lung cancer at different clinical stages and in 30 normal volunteers．Results：The plasma levels of P-sel and LN were significantly higher in patients than those in normal controls（P＜0．01）．The LN concentration of small cell type of lung cancer was higher than that of non-small cell type，but that of P-sel was not different between them．The P-sel and LN concentrations were higher in extensive small cell type than those in limited．In non-small cell type，the P-sel and LN levels at stage Ⅲ and Ⅳ were higher than those at stage Ⅱ，and so did between stage Ⅳ and Ⅲ．The plasma levels of P-sel and LN were decreased obviously in small cell type after chemotherapy．Conclusion：It is suggested that the elevation of P-sel and LN levels corresponds to the progressions of lung cancer．Detection of plasma levels of P-sel and LN may therefore provide a useful tool for monitoring the clinical course and therapeutic efficacy in patients with lung cancer．
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 17-18 )