Research progress of PPARγ and its ligands in colorectal cancer
WEI Jian-ming
HE Ting
WANG Jun-fu
Abstract：Peroxisome proliferator-activated receptor γ(PPARγ),a member of the nuclear hormone receptor su-perfamily,also functions as a tumor suppressor.Upon activation by its ligands,PPARγ can inhibit colorectal cancer cell proliferation and cell-cycle progression,suppress invasion,metastasis,and angiogenesis,and promote apoptosis.Accu-mulating evidence indicates that PPARγ regulates multiple molecular pathways involved in the initiation and progression of colorectal cancer,while its ligands exhibit significant therapeutic potential in this malignancy.PPARγ is therefore consid-ered a promising therapeutic target for colorectal cancer.This review summarizes the antitumor effects of PPARγ and its ligands,along with the underlying regulatory mechanisms implicated in colorectal cancer treatment.
Keywords：colorectal cancerPPARγligands
Publication Date：2026-01-15
Online Publishing Date：2026-03-04(First online date of this platform, not the publication date of the document)
Pages：5( 149-153 )