Serum TRAF3 and CXCR7 expression in acute ischemic stroke and their association with disease severity and prognosis
NIU Xiao-ning
YAN Wen-bo
LIANG Pan-pan
SONG Ai-xia
Abstract：Objective To investigate serum levels of tumor necrosis factor receptor-associated factor 3(TRAF3)and CXC motif chemokine receptor 7(CXCR7)in patients with acute ischemic stroke(AIS)and their relation-ships with disease severity and prognosis.Methods A total of 198 AIS patients admitted from January 2022 to January 2025 were enrolled as the study group.Patients were stratified by disease severity into mild,moderate,and severe groups and by prognosis into favorable and unfavorable outcome groups.Another 198 healthy volunteers were enrolled as controls.Serum TRAF3 and CXCR7 levels were measured using enzyme-linked immunosorbent assay(ELISA).Pearson correla-tion analysis assessed the relationships between TRAF3,CXCR7,and NIH Stroke Scale(NIHSS)and modified Rankin Scale(mRS)scores.Multivariate logistic regression identified independent risk factors for poor prognosis.Receiver oper-ating characteristic(ROC)curve analysis evaluated the predictive value of TRAF3 and CXCR7 for unfavorable outcomes.Results AIS patients exhibited higher serum TRAF3 and lower CXCR7 levels than controls(P＜0.05).TRAF3 in-creased and CXCR7 decreased progressively with stroke severity(P＜0.05).Patients with poor prognosis had higher total cholesterol,triglycerides,LDL-C,NIHSS scores at admission,onset-to-admission time,infarct area,CRP,and TRAF3 levels,and lower HDL-C and CXCR7 compared with those with good prognosis(P＜0.05).TRAF3 positively correlated with NIHSS and mRS scores,whereas CXCR7 negatively correlated(P＜0.05).Multivariate analysis indicated that total cholesterol,triglycerides,onset-to-admission time,infarct area,CRP,TRAF3,and CXCR7 were independ-ent predictors of poor prognosis(P＜0.05).ROC analysis showed that combined TRAF3 and CXCR7 yielded an AUC of 0.920,significantly higher than TRAF3(Z=2.234,P=0.025)or CXCR7(Z=2.594,P=0.009)alone.Conclu-sion Elevated serum TRAF3 and decreased CXCR7 levels in AIS patients are associated with disease severity and poor prognosis.The combination of TRAF3 and CXCR7 provides high predictive value for adverse outcomes,offering potential utility for early risk stratification.
Keywords：acute ischemic strokedisease severityprognosistumor necrosis factor receptor associated factor 3CXC motif chemokine receptor 7
Publication Date：2026-01-15
Online Publishing Date：2026-03-04(First online date of this platform, not the publication date of the document)
Pages：6( 76-81 )