Pathogenesis and early identification of refractory mycoplasma pneumoniae pneumonia in children
CHEN Zi-yu
SUN Li-hong
Abstract：The incidence and severity of refractory Mycoplasma pneumoniae pneumonia(RMPP)in children have increased in recent years.Macrolide antibiotic resistance contributes to the development of RMPP;however,some patients still benefit from these drugs,and the relationship between resistance and clinical response warrants further investigation.Differential expression of non-coding RNAs has been observed in RMPP patients,influencing multiple biological proces-ses during Mycoplasma pneumoniae(MP)infection,providing a novel perspective for understanding RMPP pathogenesis.In addition to classical biomarkers such as lactate dehydrogenase(LDH),C-reactive protein(CRP),and D-dimer,potential new predictive indicators-including vitamin A,high mobility group box 1(HMGB1),and atopic constitution-are discussed,along with predictive models.These approaches may have clinical applications for early identification of RMPP,prediction of disease severity,and guidance of therapeutic strategies.
Keywords：childrenrefractory mycoplasma pneumoniae pneumonianon-coding RNAbiomarkerspredic-tive models
Publication Date：2026-01-15
Online Publishing Date：2026-03-04(First online date of this platform, not the publication date of the document)
Pages：5( 1-5 )