Clinical value of adjunctive vitamin D therapy in children with mycoplasma pneumoniae pneumonia

ZHANG Chun-hua; ZHOU Ying; CHEN Miao-ling

doi:10.13820/j.cnki.gdyx.20252425

Abstract：Objective To evaluate the clinical value of adjunctive vitamin D therapy in children with Mycoplasma pneumoniae pneumonia(MPP)and to assess its effects on inflammatory response,immune function,and clinical out-comes.Methods A total of 348 pediatric inpatients diagnosed with MPP from January 2024 to June 2025 were enrolled.Using stratified randomization,patients were assigned to a vitamin D supplementation group or a non-supplementation group.Based on baseline vitamin D status(deficient/non-deficient),four subgroups were created:non-supplemented deficient(n=78),non-supplemented non-deficient(n=83),supplemented deficient(n=97),and supplemented non-deficient(n=90).All patients received standard anti-MP therapy;the supplementation group additionally re-ceived 400 IU of vitamin D daily.Changes in inflammatory markers(CRP,LDH,IL-6),T-lymphocyte subsets(CD4+/CD8+ratio),pulmonary function(FEV1,FVC,PEF),and length of hospital stay were compared before and af-ter treatment.Results Following treatment,CRP,LDH,and IL-6 levels were significantly lower and CD4+/CD8+ra-tios were significantly higher in both supplementation subgroups compared with the two non-supplementation subgroups(P＜0.05).Pulmonary function indices(FEV1,FVC,PEF)improved to a greater extent in the supplementation group than in the non-supplementation group,while hospital stay was significantly shorter(P＜0.05).Multivariate linear re-gression analysis identified vitamin D supplementation as an independent protective factor associated with reduced hospital-ization duration(B=-2.15,P＜0.05).Conclusion For non-severe MPP children aged 5-10 years(as defined by guideline criteria),adjunctive vitamin D-regardless of baseline vitamin D status-effectively suppresses inflammation,modulates cellular immunity,improves pulmonary function,and shortens hospital stay when added to standard therapy.