Progress in the role of meteorin-like protein in exercise-mediated prevention and treatment of metabolic disea-ses
CHEN Si-qi
HAN Xiao
PANG Wen-tao
MA Pei-hong
WU Si-nuo
TANG Dong-ning
WU Si-quan
XIA Qing
Abstract：Metabolic diseases have become a major global public health challenge,and exercise,as a safe and ef-fective non-pharmacological intervention,has been widely applied in the prevention and treatment of obesity,type 2 dia-betes mellitus(T2DM),and nonalcoholic fatty liver disease(NAFLD),yet the underlying regulatory mechanisms remain incompletely understood.Meteorin-like protein(Metrnl),also known as Subfatin,Cometin,IL-39,or IL-41,is a newly identified secreted protein associated with metabolic regulation that enhances insulin sensitivity,alleviates inflamma-tory responses,and modulates energy homeostasis,thereby playing an important role in preventing and treating obesity,T2DM,and related metabolic disorders.Notably,exercise increases Metrnl expression in metabolic tissues such as skele-tal muscle and adipose tissue.This review summarizes recent domestic and international research on the role of Metrnl in exercise-mediated prevention and treatment of metabolic diseases and analyzes its potential mechanisms of action,provi-ding a theoretical basis for novel molecular targets and interventions in the management of metabolic disorders.
Keywords：exercisemeteorin-like proteinmetabolic diseases
Publication Date：2025-12-15
Online Publishing Date：2026-01-12(First online date of this platform, not the publication date of the document)
Pages：5( 1821-1825 )