Correlations between serum vitamin D levels,visceral fat area,and urinary albumin-to-creatinine ratio in type 2 diabetes patients with different body weights
CHEN Kun
JIANG Li-yan
HU Yi-meng
WANG Xiao-hu
Abstract：Objective To investigate the relationship between serum vitamin D levels,visceral fat area(VFA),and urinary albumin-to-creatinine ratio(UACR)in type 2 diabetes(T2DM)patients with different body weights.Methods A total of 140 hospitalized T2DM patients in the Department of Endocrinology from December 2023 to May 2024 were enrolled.Height,weight,and body mass index(BMI)were measured.Laboratory tests included 25-hydroxyvitamin D3(25-OHD),fasting blood glucose,fasting insulin,HbA1C,total cholesterol,triglycerides,LDL-C,HDL-C,and UACR.Patients were grouped by abdominal VFA(＜100 cm2 vs.≥100 cm2)and by BMI.The relation-ships between BMI,25-OHD,VFA,and UACR were analyzed.Results Patients with VFA ≥100 cm2 had higher BMI and LDL-C compared with those with VFA＜100 cm2(P＜0.05).Serum 25-OHD levels were lower in the VFA ≥100 cm2 group(P＜0.05).Multivariate logistic regression analysis showed that VFA was negatively correlated with 25-OHD and positively correlated with BMI(P＜0.05).Compared with normal-weight patients,overweight/obese T2DM patients had increased VFA and decreased 25-OHD levels,with significant differences between groups(P＜0.05).UACR was negatively correlated with vitamin D levels(P＜0.05).Conclusion In hospitalized overweight/obese T2DM patients,VFA is positively correlated with BMI and independently negatively correlated with 25-OHD.UACR is nega-tively correlated with vitamin D levels.Weight reduction and vitamin D supplementation may effectively improve the prog-nosis of diabetic nephropathy in overweight/obese T2DM patients.
Keywords：type 2 diabetesvitamin Dvisceral fat areabody mass indexurinary albumin-to-creatinine ratio
Publication Date：2025-12-15
Online Publishing Date：2026-01-12(First online date of this platform, not the publication date of the document)
Pages：5( 1795-1799 )