Clinical efficacy of bifid triple viable capsules combined with Kangfuxin liquid in patients undergoing abdominal radiotherapy
HU Meng
YANG Jun
LUO Yi-jun
YAO Wei-rong
SHEN Qing-lin
Abstract：Objective To evaluate the clinical efficacy of bifid triple viable capsules combined with Kangfuxin liquid in patients receiving abdominal radiotherapy.Methods A total of 80 patients diagnosed with rectal or cervical cancer and undergoing abdominal radiotherapy at Jiangxi Provincial People's Hospital from June 2021 to December 2023 were enrolled and randomly assigned into two groups(n=40 each)using a random number table.Both groups received standard radiotherapy;the observation group received additional treatment with bifid triple viable capsules and Kangfuxin liquid enema,while the control group received Kangfuxin liquid retention enema alone.The incidence,grade,and onset time of acute radiation enteritis(ARE),as well as inflammatory cytokine levels and immune function indices,were com-pared between the two groups.Results All patients completed the study.The incidence of ARE was significantly lower in the observation group than in the control group(P＜0.05).The mean time to ARE onset was longer in the observation group(P＜0.05),while the duration of ARE was shorter but not significantly different between groups(P＞0.05).After radiotherapy,interleukin(IL)-6 and tumor necrosis factor-α(TNF-α)levels significantly increased in the observa-tion group(P＜0.05),whereas IL-6,IL-8,and TNF-α levels all increased in the control group(P＜0.05).Post-radiotherapy,CD8+T cells and CD4+/CD8+ratios in the observation group decreased significantly compared with pre-radiotherapy(P＜0.001),while CD4+T,CD8+T cells,and CD4+/CD8+ratios in the control group also declined sig-nificantly(P＜0.001).Notably,CD4+T cells and CD4+/CD8+ratios after radiotherapy were higher in the observation group compared with the control group(P＜0.001).Both groups showed lower CD4+/CD8+ratios post-radiotherapy than before treatment(P＜0.001).Conclusion The combined regimen of bifid triple viable capsules and Kangfuxin liq-uid demonstrates preventive and therapeutic benefits against acute radiation enteritis in patients undergoing abdominal ra-diotherapy,indicating potential for wider clinical application.
Keywords：abdominal malignancyradiation therapybifidobacterium bifidum triple live bacterial preparationacute radiation enteritisKangfuxin liquid
Publication Date：2025-11-15
Online Publishing Date：2026-01-06(First online date of this platform, not the publication date of the document)
Pages：5( 1671-1675 )