Research progress on large-conductance calcium-activated potassium channels
LIU Xue-qing
WU Jian-wei
QI Jian-yong
Abstract：Large-conductance calcium-activated potassium(BKCa)channels are crucial ion channels widely expressed throughout the human body.These channels have a complex structure and play essential roles in various physio-logical functions through allosteric activation.BKCa channels participate in the regulation of critical biological processes such as blood pressure,heart rate,and neural transmission.Abnormal activation or inactivation of BKCa channels can lead to prolonged action potential duration,excessive contraction of smooth muscle,or aberrant neuronal discharges,con-tributing to multiple pathological conditions.This review provides a brief overview of the structural features,functional properties,regulatory mechanisms,and physiological and pathological roles of BKCa channels,as well as their association with related diseases.The aim is to offer a comprehensive understanding and novel perspectives for further in-depth re-search into BKCa channels.
Keywords：large-conductance calcium-activated potassium channelsion channelstructure and functionresearch progress
Publication Date：2025-10-15
Online Publishing Date：2025-11-28(First online date of this platform, not the publication date of the document)
Pages：6( 1596-1600,后插1 )