Advances in the application of ultra-long-acting local anesthetics in thoracic and abdominal surgery
PENG Ying-lin
LI Shan-shan
SHE Shou-zhang
ZHENG Bin
Abstract：With the widespread implementation of Enhanced Recovery After Surgery(ERAS)protocols,perioper-ative pain management has become a key component in thoracic and abdominal surgery.Traditional local anesthetics have a short duration of action(usually less than 8 hours),which is insufficient to cover the peak period of postoperative acute pain,leading to increased opioid consumption and higher risk of related adverse effects.Ultra-long-acting local anes-thetics achieve sustained drug release through lipid-based or polymer-based carrier systems,extending analgesic dura-tion to over 72 hours and significantly improving postoperative recovery quality.This review systematically summarizes the mechanisms of action,clinical applications,safety,and technical challenges of ultra-long-acting local anesthetics in thoracic and abdominal surgery,and discusses future directions to optimize perioperative analgesic strategies.
Keywords：ultra-long-acting local anestheticsthoracic and abdominal surgeryanalgesialiposomal bupiva-caine
Publication Date：2025-10-15
Online Publishing Date：2025-11-28(First online date of this platform, not the publication date of the document)
Pages：4( 1460-1463 )