Pathological data and epidemiological characteristics of 2 623 renal biopsies from a single center

YU Yue-xin; QIN Zi-rui; LYU Li; WANG Cai-li

doi:10.13820/j.cnki.gdyx.20251127

Abstract：Objective To analyze the spectrum and epidemiological characteristics of glomerular diseases diag-nosed by renal biopsy in parts of Inner Mongolia over the past 20 years.Methods Clinical and pathological data of pa-tients who underwent renal biopsy in the Department of Nephrology,the First Affiliated Hospital of Baotou Medical Col-lege,between January 2004 and December 2023 were retrospectively reviewed.The clinical epidemiological features,pathological classifications,and incidence patterns were analyzed.Results A total of 2 623 renal biopsy cases were in-cluded,with 1 404(53.53％)males and 1 219(46.47％)females,and a mean age of(44.80±15.69)years.Com-pared with 2004-2013,the mean age of biopsy patients increased significantly in the past decade(P＜0.001).The pro-portion of IgA nephropathy(IgAN)decreased significantly over time(P＜0.05),while membranous nephropathy(MN)increased significantly(P＜0.05),replacing IgAN as the most common primary glomerular disease since 2014.Diabetic nephropathy(DN)showed the largest increase among secondary glomerular diseases(P＜0.05).The proportion of mid-dle-aged and elderly patients increased significantly in cases of MN,IgAN,minimal change disease(MCD),focal seg-mental glomerulosclerosis(FSGS),and Henoch-Schönlein purpura nephritis(HSPN)compared with a decade ago(all P＜0.05).Conclusion Over the past 20 years,the spectrum and epidemiology of glomerular diseases in Inner Mongolia have changed significantly.The average age of patients undergoing renal biopsy has increased,with a higher proportion of middle-aged and elderly patients.MN has become the most common primary glomerular disease in this center.