Differentiation of intrahepatic mass-forming cholangiocarcinoma and hepatocellular carcinoma using CT histo-gram texture analysis
ZHAO Meng-fei
HOU Juan
GONG He-jun
ZHANG Lei
LIU Wen-ya
Abstract：Objective To evaluate the diagnostic value of CT histogram texture features in differentiating intrahe-patic mass-forming cholangiocarcinoma(IMCC)from hepatocellular carcinoma(HCC).Methods A retrospective analysis was conducted on contrast-enhanced CT images from 34 patients with pathologically confirmed IMCC and 31 pa-tients with HCC.Texture analysis software was used to extract first-order grayscale histogram features,including mean,variance,skewness,kurtosis,and percentiles(1％,10％,50％,90％,99％)across arterial,portal venous,and equi-librium phases.Statistical analysis was performed to assess the diagnostic performance of these features.Results Among individual texture features,the 10th percentile(perc10)during the portal venous phase showed the highest diagnostic val-ue with an AUC of 0.771,sensitivity of 79.4％,and specificity of 71.0％.Combined texture parameters in the equilibri-um phase yielded the highest overall diagnostic performance with an AUC of 0.884,sensitivity of 97.1％,and specificity of 77.4％.Conclusion CT-based histogram texture analysis provides valuable information for differentiating IMCC from HCC,with equilibrium-phase texture features showing the greatest diagnostic efficacy.
Keywords：intrahepatic cholangiocarcinomahepatocellular carcinomaimage enhancementtexture analysis
Publication Date：2025-08-15
Online Publishing Date：2025-11-06(First online date of this platform, not the publication date of the document)
Pages：7( 1167-1173 )