Comparison of intrauterine infusion of platelet-rich plasma and granulocyte colony-stimulating factor on clini-cal outcomes of frozen-thawed embryo transfer in patients with thin endometrium
LIANG Yi-hua
LIN Li-ting
XIE Xiao-zhen
ZHANG Jia-ning
JIAO Xue-dan
WU Yao-qiu
DU Tao
CHEN Hui
ZHANG Qing-xue
Abstract：Objective To evaluate the clinical efficacy of intrauterine infusion of platelet-rich plasma(PRP)and granulocyte colony-stimulating factor(G-CSF)by comparing pregnancy outcomes of frozen-thawed embryo trans-fer(FET)cycles in infertile patients with thin endometrium.Methods A retrospective analysis was conducted on 51 FET cycles treated with autologous PRP.The PRP group was further subdivided based on endometrial thickness(＜7 mm and ≥7 mm)to compare clinical outcomes.Cycles with endometrial thickness＜7 mm were also compared with 61 con-trol cycles(no intervention)and 30 cycles treated with intrauterine G-CSF infusion.Results Among patients receiving PRP,the endometrial thickness was 6.50 mm in the＜7 mm group,with 44.45％having moderate to severe intrauterine adhesions,compared to 7.90 mm and 27.27％in the ≥7 mm group.There were no statistically significant differences in clinical pregnancy rate(27.78％vs.30.30％)or embryo implantation rate(20.0％vs.22.73％)between the two sub-groups.A significantly higher proportion of patients in the PRP(＜7 mm)group had a history of intrauterine adhesions(83.33％)compared to the control(49.18％)and G-CSF(50.0％)groups.The three groups had comparable endom-etrial thickness before embryo transfer.The clinical pregnancy rates in the control,PRP,and G-CSF groups were 26.23％,27.78％,and 20.0％,respectively,and implantation rates were 20.2％,20.0％,and 13.3％,respectively,with no statistically significant differences among the groups.Conclusion Intrauterine infusion of PRP may offer potential clinical value in FET for patients with severely thin endometrium.
Keywords：thin endometriumplatelet-rich plasmagranulocyte colony-stimulating factorintrauterine infusion
Publication Date：2025-07-15
Online Publishing Date：2025-08-25(First online date of this platform, not the publication date of the document)
Pages：6( 983-988 )