Efficacy of Compound Fresh Bamboo Leach Liquid combined with bronchoalveolar lavage in treating severe mycoplasma pneumoniae lobar pneumonia in children
LIU Dong-mei
WANG Jing-min
XU Lin
WANG Ya-nan
HOU Xiu-ling
Abstract：Objective To analyze the clinical efficacy of Compound Fresh Bamboo Leach combined with bron-choalveolar lavage(BAL)in treating severe mycoplasma pneumoniae(MP)lobar pneumonia in children and its impact on immune-inflammatory status.Methods A total of 104 children with severe MP lobar pneumonia admitted from January 2022 to January 2024 were randomly divided into two equal groups.The control group received BAL treatment,while the observation group received additional Compound Fresh Bamboo Leach.After two weeks of treatment,clinical efficacy was evaluated.The two groups were compared in terms of major symptom scores,pneumonia chest X-ray absorption evalua-tion scale(PCRAES),clinical pulmonary infection score(CPIS),and immune-inflammatory indicators,including com-plement C3,C4,CD3+human leukocyte antigen-DR(CD3+HLA-DR),natural killer(NK)cells,serum amyloid A(SAA),interleukin-33(IL-33),and soluble intercellular adhesion molecule-1(sICAM-1).Adverse reactions were recorded.Results The total effective rate was significantly higher in the observation group(94.23％,49/52)than in the control group(80.77％,42/52)(P＜0.05).Symptom scores(fever,cough,sputum volume,sputum properties,chest pain,lung rales)decreased significantly after treatment in both groups(P＜0.05)and were significantly lower in the observation group than in the control group after treatment(P＜0.05).Post-treatment,PCRAES,CPIS,and serum levels of C3,C4,SAA,IL-33,and sICAM-1 were significantly reduced in both groups(P＜0.05),while peripheral blood CD3+HLA-DR and NK cell levels were significantly increased(P＜0.05),with a more pronounced effect in the observation group(P＜0.05).The incidence of adverse reactions was 7.69％(4/52)in the observation group and 5.77％(3/52)in the control group,with no significant difference between the two(P＞0.05).Conclusion The com-bination of compound fresh bamboo leach with BAL significantly improves the clinical efficacy of treating severe MP lobar pneumonia in children,enhances symptom relief,and reduces pulmonary infection.Its mechanism may be related to better immune function regulation and inhibition of inflammatory responses.
Keywords：childrenimmunoinflammatory responsesevere pneumoniaFresh Bamboo Leach Compoundmy-coplasma pneumoniaebronchoalveolar lavagelobar pneumonia
Publication Date：2025-05-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 641-647 )