Prognostic evaluation of serum galectin-3,high-sensitivity cardiac troponin T,and C1q tumor necrosis factor-related protein 3 in elderly heart failure patients with arrhythmias
LU Hou-xin
LIU Jia
HAN Ke-li
LI Xin-guo
Abstract：Objective To investigate the combined application of serum galectin-3(Gal-3),high-sensitivity cardiac troponin T(hs-cTnT),and C1q tumor necrosis factor-related protein 3(CTRP3)for the prognostic evaluation of elderly heart failure(HF)patients with arrhythmias.Methods A total of 208 elderly patients with chronic HF were selected and divided into two groups:HF with atrial fibrillation(AF)group and HF group.A healthy control group of 80 individuals was also included.Clinical data were collected,and serum levels of Gal-3,hs-cTnT,and CTRP3 were measured.Follow-up was conducted to observe events of recurrent HF,arrhythmias,and cardiovascular death in the HF with AF group.Cox regression analysis was used to identify factors affecting prognosis in the HF with AF group.Receiver operating characteristic(ROC)curve analysis was used to evaluate the diagnostic and prognostic value of serum Gal-3,hs-cTnT,and CTRP3.Results In comparison with the healthy control group,NT-proBNP,Gal-3,hs-cTnT,and left atrial diameter(LAD)were higher,while left ventricular ejection fraction(LVEF)and CTRP3 were lower in both HF and HF with AF groups(P＜0.05).In the HF with AF group,NT-proBNP,Gal-3,and hs-cTnT were higher,while CTRP3 was lower compared to the HF group(P＜0.05).In the poor prognosis group,the proportion of patients with NY-HA functional class Ⅳ was higher,and NT-proBNP,LAD,Gal-3,and hs-cTnT levels were higher,while LVEF and CTRP3 were lower compared to the good prognosis group(P＜0.05).NT-proBNP(HR=2.053),Gal-3(HR=3.022),and hs-cTnT(HR=3.165)were identified as risk factors for poor prognosis in the HF with AF group,while LVEF(HR=0.126)and CTRP3(HR=0.433)were protective factors(P＜0.05).The combined detection of serum Gal-3,hs-cTnT,and CTRP3 had a higher prognostic value for poor outcomes in the HF with AF group(AUC=0.903)compared to individual tests(AUC=0.797,AUC=0.767,AUC=0.796)(ZGal-3=2.244,Zhs-cTnT=2.654,ZCTRP3=2.409,P＜0.05).Conclusion In elderly HF patients with arrhythmias,serum Gal-3 and hs-cTnT levels are elevat-ed,while CTRP3 levels are reduced.Compared with those with good prognosis,patients with poor prognosis have higher levels of Gal-3 and hs-cTnT and lower CTRP3 levels.The combined detection of serum Gal-3,hs-cTnT,and CTRP3 can be used for prognostic evaluation and prediction in these patients.
Keywords：elderly heart failurearrhythmiasgalectin-3high-sensitivity cardiac troponin TC1q tumor necrosis factor-related protein 3prognosis
Publication Date：2025-04-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 532-537 )